Category Archives: Seminar

Prof Andrey Rzhetksy: “Computational Analysis of Complex Human Disorders”

From Jason Alvey at KCL:

You are invited to a Special Guest Lecture to be held on Thursday, 21st February 2013, at 3:30 – 4:30pm in Small Lecture Theatre, First Floor, Main Building, Institute of Psychiatry, Denmark Hill Campus.

Professor Andrey Rzhetsky, Department of Human Genetics, University of Chicago

Computational analysis of complex human disorders’

Focusing on autism, bipolar disorder and schizophrenia, my talk will touch the following questions. How understanding of genetics and epidemiology of disease can be advanced through modeling and computational analysis of very large and heterogeneous datasets?  What are the bottlenecks in analysis of complex human maladies?  How can we model and compute over multiple data types to narrow hypotheses about genetic causes of disease?  How collaborations across multiple fields of science can bring translational results to initially purely academic studies?

Andrey Rzhetsky is a Professor of Medicine and Human Genetics, at the University of Chicago. He is also a Pritzker Scholar, and a Senior Fellow of both the Computation Institute, and the Institute for Genomics and Systems Biology at the University of Chicago. His research is focused on computational analysis of complex human phenotypes in context of changes and perturbations of underlying molecular networks. The input data for these studies is supplied by large-scale mining of free text, computation over clinical records, and high-throughput systems biology experiments.  Most recently in 2011, Rzhetsky was awarded a $13.7 million grant from the National Institutes of Health titled “Conte Center for Computational Systems Genomics of Neuropsychiatric Phenotypes.” This five-year project involves investigators from seven institutions across the United States and Israel who will study new computational methodology for the analysis of multiple complex mental health disorders, such as autism and schizophrenia.


KCL Denmark Hill Bioinformatics seminars

Hey guys,

At Denmark Hill KCL SGDP department the Biomedical Research Centre for Mental Health we are running a monthly seminar series. For full details see “ You are welcome to attend.

All the best, Steve

Provisional seminar schedule (all sessions in KCL Denmark Hill campus SGDP seminar room A/B)

October 30th 3:30-4:00pm

Dr. Thomas Schlitt

Two network analysis approaches for the identification of disease associated genes

November 30th 3-4pm

Dr. Matt Davies

“Machine Learning Approaches to the Metabolome”

Dr. James Swingland

“1-D Spatial modelling of gene expression data”, followed by a demonstration of chromowave.


January 29th 3-4pm

Dr. Natasa Przulj, Imperial College

“Network Topology as a Source of Biological Information”


February 26th 3-4pm

Grace Lu

“Is the Interface of 3D Protein Complexes a Determinant in the Pathogenesis of Disease-related Genes?”

Jennifer Mollon – TBA


March 26th 3-4pm – TBA


April 30th 3-4pm

Dr. Michael Barnes, QMUL

“Drug repositioning in silico”


May 28th 3-4pm

Dr Robert Eriksson, Technical University Denmark

“Undesired drug effect identification in Danish electronic patient records”

Imperial College Centre for Integrative Systems Biology and Bioinformatics Seminar Series

All are welcome to the following CISBIO seminars – venues as listed:

Monday Feb 13th, 4.30pm
7th Floor common room
Sir Ernst Chain Building – Wolfson Laboratories (formerly Biochemistry)

Dr Guido Sanguinetti,
University of Edinburgh

Latent switching models of transcriptional regulation

Abstract: I will review the use of a class of continuous-time models of transcriptional regulation. This consist of a system of (ordinary or stochastic) differential equations whose coefficients depend on a latent, discrete state Markov Jump process. The interpretation we will propose is that the DEs describe the dynamics of expression of a set of genes, while the latent processes describe activation states of transcription factor proteins. I will describe the approach to inference, and present results on a number of real data sets.

Monday 5th March, 4 pm
G34 Lecture Theatre, SAF (Sir Alexander Fleming) building

Dr Nick Le Novère
EMBL – European Bioinformatics Institute

This or that – Allosteric Calcium Sensors and Synaptic Plasticity

Monday 12th March, 4pm
G34 Lecture Theatre, SAF (Sir Alexander Fleming) building

Dr Mario Caccamo
The Genome Analysis Centre (TGAC)

Computational analysis of next generation sequencing (provisional title)

Monday 26th March, 4.30pm
Rm 122, SAF (Sir Alexander Fleming) building

Prof Jürg Bähler,
University College London

Quantitative Analysis of Fission Yeast Transcriptomes and Proteomes

21/02/2012 Translational Bioinformatics Seminar

BRC Methodology Collaboration: Translational Bioinformatics Seminar
21st Feb 12.30-17.00

If you would like to attend, please email with subject “register”

Download Flyer

Lecture Theatre,
30th Floor, Tower Wing,
Guy’s Campus,
King’s College London,
London Bridge
London SE1 9RT


12.30: Buffet Lunch

13.00: Prof. Tom Coolen – What you see is not what you get: how sampling affects macroscopic features of biological networks

13.30: Dr. Davide Bacciu – Learning Bayesian Network skeletons with high-dimensional and large-sample size data

14.00: Prof. Alfonso Valencia – Computational challenges in Personalized Medicine

14.30: Tea Break

15.00: Dr. Eric Yang – Combining Disparate Clinical Datasets for Integrated Analysis

3.30: Dr. Paolo Vigneri – The Untouchables: mapping critical residues in the BRC-ABL catalytic domain to understand TKI resistance in Chronic Myeloid Leukemia

16.00: Prof. Peter Coveney – Computational Biomedicine: A Challenge for the Twenty-First Century

16.30: Dr. Nour Shublaq – Getting Personal through Translational Bioinformatics: The Future Now

17:00: Visit to local pub, or move to Lecture Theatre 1, New Hunt’s House, KCL (SE1 1UL) for the next talk in the King’s International Lecture Series: Prof. Mark Musen – Becoming a meta-physician: better clinical information for the future of healthcare

Dev8D 2011

Dev8D Logo

JISC-funded un-conference for developers in higher education and research

See the Dev8D website for details and to book a place

“The aim of Dev8D is to bring together developers from across the education sector and wider in order to learn from one another and ultimately create better, smarter technology for learning and research”

26/11 Mendeley Event

The Mendeley folks are running a seminar on publishing papers, promoting your research and how their search and recommendation algorithms work.

There will also be beer, snacks and foosball

More details on the Mendeley Blog

KCL Bioinformatics Interest Group (BIG)

23rd of November, 2-5.30

== Venue ==
Wolfson Lecture Theatre, Institute of Psychiatry, Denmark Hill

== Program ==

Thomas Schlitt and Michael Simpson (Bioinformatics/Medical
and Molecular Genetics, KCL)
Exome sequencing lessons and strategies.

Francesca Ciccarelli (FIRC Institute of Molecular Oncology
and European Institute of Experimental Oncology (IFOM-IEO))
Quantification of genome instability of tumour cells using
next-generation sequencing (NGS)

20 min tea break.

3.40 – 4.20
Elia Stupka (Scientific Director – Bioinformatics, UCL
Genomics and Senior Lecturer, Bioinformatics)
Do we understand enough about genomes to build next generation molecular networks of disease?

Jeff Barrett (Sanger Centre)
The UK10K (10,000 genomes) project and imputation of variants in whole
genome sequencing.

== Registration ==

Please contact Gerome Breen at KCL to RSVP